DELTHAmannosio ®



  • Complex of high-dose D-mannose (1000 mg), purified nucleotides and Cranberry titrated in HPLC
  • Adjuvant in treating and preventing acute and recurrent cystitis and in counteracting their symptoms
  • A natural help to strengthen the natural bladder defenses
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Food supplements based on D-Mannose, Ribodiet nucleotides and Cranberry.
Their synergistic action is used to support the body’s natural defences in general and the urinary tract in particular.

D-mannose is a monosaccharide that is not metabolized by the body and therefore largely eliminated as such through the urine. For this reason, it is an adjuvant in the resolution of that typical and annoying condition known as cystitis. Cystitis is an inflammation of the bladder, which in a high percentage of cases is caused by facultative anaerobic bacteria that originate from the intestinal flora, such as Escherichia coli. This bacterium has tentacular structures on its surface called fimbriae or pili that can adhere to the epithelial cells of the bladder mucosa. D-mannose interferes with this microbial adhesion mechanism by promoting urinary elimination of the micro-organisms.

Ribodiet’s purified nucleotides, the only ones on the market, are recognized in international literature for their usefulness in boosting and supporting the immune system. In addition, Ribolife’s activity in rebalancing intestinal microflora, a known and possible contributory cause of cystitis, is well documented.

Cranberry is a botanical ingredient traditionally used in the treatment of urinary infections thanks to its mechanism of action, which is linked to the presence of proanthocyanins, substances capable of inhibiting microbial adhesion to the bladder mucosa. By preventing this attachment, in synergy with D-mannose, bacterial implantation is inhibited.


Product included in the supplement register of the Italian Ministry of Health under the no. 61513


Composition: 1 sachet

D-mannose 1000 mg
Marsh Cranberry (titrated to 25% PAC in HPLC) 40 mg
Nucleotides 230 mg

Raw materials

A complex of high-dose D-mannose, purified RIBODIET nucleotides and HPLC-titrated cranberry, indicated as an adjunct in the treatment and prevention of acute and recurrent cystitis and to combat its symptoms.

Delthamannosio contains a high dose (1000 mg) of D-mannose, a monosaccharide extracted from larch and birch bark. D-mannose has unique characteristics: it is not metabolized by the body; it is highly soluble and is excreted intact and completely in the urinary tract. As such, it reaches the urinary system in an effective quantity and may create complexes with uropathogenic bacteria, first of all Escherichia Coli, responsible for 90% of cystitis, blocking its ability to adhere and colonize the urinary tract. Thanks to its mechanism of action, it has the advantage of being effective even in the presence of any resistance to antibiotics and can act in synergy with the antibiotics themselves, therefore it is used both as an adjunct in treatment and in preventing cystitis recurrences. Even if it belongs to the class of sugars, Delthamannosio can also be used by diabetic subjects because it is not absorbed systemically.

Cranberry (Vaccinium macrocarpon)
Delthamannosio contains Cranberry (40 mg) or American cranberry, known to Native Americans for its beneficial action on urinary tract infections, in osteoporosis and as a source of antioxidants. The properties of the Cranberry are due to Proanthocyanins (PACs), polyphenols that inhibit the adhesion of bacteria to the walls of the urinary tract, present in the berries whose dry extract is used. PACs are extracted using HPLC (High Performance Liquid Chromatography), ie by passing the raw material into columns under a pressure of hundreds of atmospheres, managing to achieve a final titration of 25%.
The standardized quantity of active principle allows the anti-adhesive action to be carried out optimally in synergy with D-mannose.

Delthamannosio contains a mixture of purified free nucleotides (230 mg) unique on the market, produced with the patented RIBODIET method (44-48% free nucleotides). In Delthamannosio there are 4 totally-natural purified nucleotides derived from yeast by enzymatic hydrolysis, therefore already in the optimal form for high absorption: AMP (adenosine 5’monophosphate: 13%), GMP (guanosine 5’monophosphate: 15%), CMP ( cytidine 5′ monophosphate: 10%) and UMP (uridine 5’monophosphate: 11%).
Nucleotides are the basic units of nucleic acids DNA (deoxyribonucleic acid) and RNA (ribonucleic acid), composed of a sugar with 5 carbon atoms, a purine or pyrimidine nitrogenous base and a phosphate group. It is the presence of the nitrogenous base (adenosine, guanine, cytosine, thymine or uracil) that characterizes the nucleotide. Nucleotides play a central role in all cellular activities, from replication to protein synthesis, to signal transduction mechanisms already in basal conditions and even more in high turnover situations, such as in epithelial tissues and mucous membranes and during inflammatory processes, where the repair of damage and the restitutio ad integrum are more relevant than in normal situations. In addition, nucleotides have shown immunomodulatory properties and ability to rebalance and promote the activity of bacterial flora at the gastrointestinal level, whose alteration (dysbiosis) is often a cause of cystitis.

How to use

DELTHAmannosio® is formulated in convenient sachets with a pleasant taste to be taken 1 sachet a day dissolved in a glass of water. It is recommended to empty the bladder before use.