EPATOril plus ®
- High dosage of Silybum Marianum (400 mg) providing high content in Silymarin (titration 80%)
- Innovative and high bioavailable formulation of phytosomal Turmeric (Meriva®)
- A synergy of hepatoprotective and anti-inflammatory principles to support liver functions
Food supplement of Silybum Marianum with high titer in Silymarin and Turmeric phospholipid.
The liver is particularly exposed to the damaging action of substances of either exogenous (alcohol, drugs, virus, etc.) and endogenous origin (metabolic disorders like hemochromatosis, glycogen storage disease, etc) that can lead to rising of transaminases up to liver fibrosis and malfunction.
It is for these reasons that the maintenance of the integrity and correct functioning of the liver is necessary to safeguard the health of the individual. In Epatoril Plus there is a high dose of Milk Thistle (400 mg) titrated at 80% in Silymarin. One of the strengths of Deltha Pharma’s products is the high dosage of raw materials, which is essential as the effectiveness of the product is strictly dose dependent.
Turmeric is a spice with a particular ability to counteract inflammatory processes in the body, and is even described in a paper for the American Academy of Pain Management  as the most powerful natural anti-inflammatory in the world. It has antiseptic and pain-relieving properties, and recent studies conducted by the University of California  have shown that Curcuma can block the action of an enzyme believed to be responsible for the development of certain cancers.
The turmeric in Epatoril Plus is a patented formulation of Curcuma Longa and soya lecithin called Meriva®, which guarantees a much higher overall absorption of curcuminoids than unformulated turmeric.
The synergistic action of these components in Epatoril Plus is used in all cases of disturbance of hepatic trophism, i.e. in cases of fatty liver, steatosis or steatohepatitis, NAFLD (non-alcoholic fatty lever disease), ASH (alcoholic steato hepatitis) and NASH (non-alcoholic steato hepatitis).
The usage is recommended in all cases of disorders of hepatic tropism.
Product included in the supplement register of the Italian Ministry of Health under the no. 61418
Composition: 1 tablet
Milk Thistle fruit (tit.80%) 400,00 mg
Sylimarin 320,00 mg
Meriva®-phospholipid Turmeric rhizome 100,00 mg
Curcuminoids 18 mg
Food supplement from the combination of Milk thistle and Phytosomal turmeric (Meriva®) for a correct liver functionality.
Milk thistle (Silybum marianum)
In Epatoril Plus there is a high dose of Milk Thistle (400 mg), a plant known since ancient times for its beneficial effects on the liver. The properties of Cardo Mariano are due to Silimarina, naturally present in fruits (seeds) in a percentage of 4%, extracted with methods that guarantee a high content of active ingredient: it is in fact titrated to 80% (320 mg of Silymarin). Another feature is the high purity, so the absence of allergens and contaminants. Moreover, the Cardo Mariano used is exclusively of Italian origin.
Silymarin is a mixture composed mostly of three flavonolignans: Silibina, Silidianina and Silicristina. Taken together, these substances have shown antioxidant properties (ability to increase hepatic levels of glutathione) and hepatoprotective, are able to accelerate the regenerative processes of the liver because they increase the metabolic activity of hepatocytes, have action of defense against hepatotoxic substances, alcohol and toxins as they block their penetration into the cells. As such, Silymarin is used in liver disorders, hepatitis, cirrhosis of the liver, intoxication and poisoning, digestive disorders related to liver dysfunction, alcoholic steatosis and problems due to alcoholism.
In addition, silymarin would favor the production of breast milk, silibine and silicristine exert a protective effect on the kidneys from cell damage caused by paracetamol and studies on the role of silymarin in the control of glycemia and neoplastic cells are underway.
In Epatoril Plus a particular Curcuma is used, formulated with soy lecithin, called Meriva. The active ingredient of turmeric is curcumin, known and used since ancient times for its extraordinary anti-inflammatory, antioxidant and pain-relieving properties, the latter thanks to its ability to act specifically on nociceptors, ie on the terminations of sensory neurons that signal tissue damage and allow painful sensations to be transmitted to the brain. Recent studies also document its antitumor and cardioprotective activity (source: Effects of Curcuminoids on Frequency of Acute Myocardial Infarction After Coronary Artery Bypass Grafting-journal of Cardiology). It is necessary, however, to underline that curcumin is not the only active ingredient of Turmeric, in it there are two other equally important active ingredients: Demetossicurcumin and Bisdemetossicurcumina, which have therapeutic properties comparable to curcumin itself. We therefore speak, more appropriately, of Curcuminoidi.
Extractive curcumin has some critical aspects, including two particularly important ones: a low intestinal absorption and a high hepatic first pass metabolism (destruction of the active ingredients during the passage through the liver, before reaching the systemic blood circulation). These problems make the extractive curcumin little bioavailable and, consequently, prevent the active ingredients from fully carrying out their therapeutic activity in the organism.
To overcome this problem in the Epatoril Plus, Meriva® is used: curcumin phytosome®. Phytosomes (from the Greek, phytón = PLANT and soma = BODY) are plant-based complexes that bind curcumin (and other curcuminoids) to phospholipids capable of improving the bioavailability of the active ingredient. Meriva® allows to convey the curcumin and the other two curcuminoids so that, through pinocytosis (modality of penetration of the molecules inside the cell), they can enter intestinal cells (enterocytes) and be conveyed into the lymphatic circulation thus bypassing the first pass metabolism hepatic. In this way the 3 curcuminoids will be able to enter the systemic blood circulation reaching directly the sites of action where they will carry out their activity.
It is for these reasons that phytosomal Curcuma guarantees an absorption about 30 times greater than that not formulated.
How to use
We recommend taking 1 tablet a day or as prescribed by a doctor.